Combining Machine Learning and Optimization Techniques to Determine 3-D Structures of Polypeptides

Dorn, Márcio; Buriol, Luciana S.; Lamb, Luís C.

doi:10.5591/978-1-57735-516-8/IJCAI11-469

Combining Machine Learning and Optimization Techniques to Determine 3-D Structures of Polypeptides

Márcio Dorn, Luciana S. Buriol, Luís C. Lamb

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Proceedings of the Twenty-Second International Joint Conference on Artificial Intelligence. Pages 2794-2794.

https://doi.org/10.5591/978-1-57735-516-8/IJCAI11-469

Abstract

One of the main research problems in Structural Bioinformatics is the analysis and prediction of three-dimensional structures (3-D) of polypeptides or proteins. The 1990’s Genome projects resulted in a large increase in the number of protein sequences. However, the number of identified 3-D protein structures has not followed the same trend.The determination of protein structure is experimentally expensive and time consuming. This makes scientists largely dependent on computational methods that can predict correct 3-D protein structures only from extended and full amino acid sequences. Several computational methodologies and algorithms have been proposed as a solution to the Protein Structure Prediction (PSP) problem. We briefly describe the AI techniques we have been used to tackle this problem.

Márcio Dorn, Luciana S. Buriol, and Luís C. Lamb. 2011. Combining Machine Learning and Optimization Techniques to Determine 3-D Structures of Polypeptides. In Proceedings of the Twenty-Second International Joint Conference on Artificial Intelligence, IJCAI-11. IJCAI, 2794–2794. https://doi.org/10.5591/978-1-57735-516-8/IJCAI11-469

@inproceedings{ijcai2011p469,
  title     = {Combining Machine Learning and Optimization Techniques to Determine 3-D Structures of Polypeptides},
  author    = {Dorn, Márcio and Buriol, Luciana S. and Lamb, Luís C.},
  booktitle = {Proceedings of the Twenty-Second International Joint Conference on
               Artificial Intelligence, {IJCAI-11}},
  publisher = {AAAI Press/International Joint Conferences on Artificial Intelligence},
  editor    = {Toby Walsh},
  pages     = {2794--2794},
  year      = {2011},
  month     = {7},
  doi       = {10.5591/978-1-57735-516-8/IJCAI11-469},
  url       = {https://doi.org/10.5591/978-1-57735-516-8/IJCAI11-469},
}

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TI  - Combining Machine Learning and Optimization Techniques to Determine 3-D Structures of Polypeptides
AU  - Dorn, Márcio
AU  - Buriol, Luciana S.
AU  - Lamb, Luís C.
T2  - Proceedings of the Twenty-Second International Joint Conference on Artificial Intelligence, IJCAI-11
PB  - AAAI Press/International Joint Conferences on Artificial Intelligence
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SP  - 2794
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DO  - 10.5591/978-1-57735-516-8/IJCAI11-469
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