{"type":"ScholarlyArticle","title":"Combining Machine Learning and Optimization Techniques to Determine 3-D Structures of Polypeptides","authors":[{"name":"Márcio Dorn","slug":"marcio-dorn","given":"Márcio","family":"Dorn","affiliation":""},{"name":"Luciana S. Buriol","slug":"luciana-s-buriol","given":"Luciana S.","family":"Buriol","affiliation":""},{"name":"Luís C. Lamb","slug":"luis-c-lamb","given":"Luís C.","family":"Lamb","affiliation":""}],"abstract":"One of the main research problems in Structural Bioinformatics is the analysis and prediction of three-dimensional structures (3-D) of polypeptides or proteins. The 1990’s Genome projects resulted in a large increase in the number of protein sequences. However, the number of identified 3-D protein structures has not followed the same trend.The determination of protein structure is experimentally expensive and time consuming. This makes scientists largely dependent on computational methods that can predict correct 3-D protein structures only from extended and full amino acid sequences. Several computational methodologies and algorithms have been proposed as a solution to the Protein Structure Prediction (PSP) problem. We briefly describe the AI techniques we have been used to tackle this problem.","doi":"10.5591/978-1-57735-516-8/IJCAI11-469","url":"https://ijcai.org/proceedings/2011/469","pdf":"https://ijcai.org/proceedings/2011/0469.pdf","markdown":"https://ijcai.org/proceedings/2011/469.md","bibtex":"https://ijcai.org/proceedings/2011/bibtex/469","volume":{"slug":"2011","title":"Proceedings of the Twenty-Second International Joint Conference on Artificial Intelligence","short_title":"IJCAI 2011","url":"https://ijcai.org/proceedings/2011/","year":2011,"location":"Barcelona, Catalonia, Spain","dates":"16–22 July 2011","editors":"Toby Walsh","isbn":"978-1-57735-512-0; 978-1-57735-513-7; 978-1-57735-514-4; 978-1-57735-515-1; 978-1-57735-516-8","publisher":"AAAI Press/International Joint Conferences on Artificial Intelligence","doi_prefix":""},"section":null,"track":"","number":469,"pages":{"first":2794,"last":2794},"keywords":[],"videos":[],"references":[],"license_note":"Copyright International Joint Conferences on Artificial Intelligence."}