According to theWorld Health Organization, Pneumoconiosis affects millions of workers globally, with an estimated 260,000 deaths annually. The burden of Pneumoconiosis is particularly high in low-income countries, where occupational safety standards are often inadequate, and the prevalence of the disease is increasing rapidly. The reduced availability of expert medical care in rural areas, where these diseases are more prevalent, further adds to the delayed screening and unfavourable outcomes of the disease. This paper aims to highlight the urgent need for early screening and detection of Pneumoconiosis, given its significant impact on affected individuals, their families, and societies as a whole. With the help of low-cost machine learning models, early screening, detection, and prevention of Pneumoconiosis can help reduce healthcare costs, particularly in low-income countries. In this direction, this research focuses on designing AI solutions for detecting different kinds of Pneumoconiosis from chest X-ray data. This will contribute to the Sustainable Development Goal 3 of ensuring healthy lives and promoting well-being for all at all ages, and present the framework for data collection and algorithm for detecting Pneumoconiosis for early screening. The baseline results show that the existing algorithms are unable to address this challenge. Therefore, it is our assertion that this research will improve state-of-the-art algorithms of segmentation, semantic segmentation, and classification not only for this disease but in general medical image analysis literature.