Baseline Regularization for Computational Drug Repositioning with Longitudinal Observational Data

Kuang, Zhaobin; Thomson, James A.; Caldwell, Michael; Peissig, Peggy L.; Stewart, Ron M.; Jr., C. David Page

Baseline Regularization for Computational Drug Repositioning with Longitudinal Observational Data

Zhaobin Kuang, James A. Thomson, Michael Caldwell, Peggy L. Peissig, Ron M. Stewart, C. David Page Jr.

Download BibTeX Cite

Proceedings of the Twenty-Fifth International Joint Conference on Artificial Intelligence. Pages 2521-2527.

Abstract

Computational Drug Repositioning (CDR) is the knowledge discovery process of finding new indications for existing drugs leveraging heterogeneous drug-related data. Longitudinal observational data such as Electronic Health Records (EHRs) have become an emerging data source for CDR. To address the high-dimensional, irregular, subject and time-heterogeneous nature of EHRs, we propose Baseline Regularization (BR) and a variant that extend the one-way fixed effect model, which is a standard approach to analyze small-scale longitudinal data. For evaluation, we use the proposed methods to search for drugs that can lower Fasting Blood Glucose (FBG) level in the Marshfield Clinic EHR. Experimental results suggest that the proposed methods are capable of rediscovering drugs that can lower FBG level as well as identifying some potential blood sugar lowering drugs in the literature.

Zhaobin Kuang, James A. Thomson, Michael Caldwell, Peggy L. Peissig, Ron M. Stewart, and C. David Page Jr.. 2016. Baseline Regularization for Computational Drug Repositioning with Longitudinal Observational Data. In Proceedings of the Twenty-Fifth International Joint Conference on Artificial Intelligence, IJCAI-16. IJCAI, 2521–2527. https://ijcai.org/proceedings/2016/359

@inproceedings{ijcai2016p359,
  title     = {Baseline Regularization for Computational Drug Repositioning with Longitudinal Observational Data},
  author    = {Kuang, Zhaobin and Thomson, James A. and Caldwell, Michael and Peissig, Peggy L. and Stewart, Ron M. and Jr., C. David Page},
  booktitle = {Proceedings of the Twenty-Fifth International Joint Conference on
               Artificial Intelligence, {IJCAI-16}},
  publisher = {AAAI Press / International Joint Conferences on Artificial Intelligence},
  editor    = {Subbarao Kambhampati},
  pages     = {2521--2527},
  year      = {2016},
  month     = {7},
  url       = {https://ijcai.org/proceedings/2016/359},
}

TY  - CPAPER
TI  - Baseline Regularization for Computational Drug Repositioning with Longitudinal Observational Data
AU  - Kuang, Zhaobin
AU  - Thomson, James A.
AU  - Caldwell, Michael
AU  - Peissig, Peggy L.
AU  - Stewart, Ron M.
AU  - Jr., C. David Page
T2  - Proceedings of the Twenty-Fifth International Joint Conference on Artificial Intelligence, IJCAI-16
PB  - AAAI Press / International Joint Conferences on Artificial Intelligence
PY  - 2016
SP  - 2521
EP  - 2527
UR  - https://ijcai.org/proceedings/2016/359
ER  -