---
title: "Qualitative Simulation of Genetic Regulatory Networks: Method and Application"
authors:
  - "Hidde de Jong"
  - "Michel Page"
  - "Céline Hernandez"
  - "Johannes Geiselmann"
doi: ""
url: "https://ijcai.org/proceedings/2001/9"
pdf: "https://ijcai.org/proceedings/2001/0009.pdf"
venue: "Proceedings of the Seventeenth International Joint Conference on Artificial Intelligence"
year: 2001
pages: "67-72"
track: ""
keywords:
---

# Qualitative Simulation of Genetic Regulatory Networks: Method and Application

Hidde de Jong, Michel Page, Céline Hernandez, Johannes Geiselmann

*Proceedings of the Seventeenth International Joint Conference on Artificial Intelligence*, pages 67-72.

## Abstract

Computer modeling and simulation are indispensable for understanding the functioning of an organism on a molecular level. We present an implemented method for the qualitative simulation of large and complex genetic regulatory networks. The method allows a broad range of regulatory interactions between genes to be represented and has been applied to the analysis of a real network of biological interest, the network controlling the inititation of sporulation in the bacterium B. subtilis.